Transcranial Assessment and Visualization of Cavitation
The interaction of ultrasonically-controlled m crobubble oscillations (acoustic cavitation) with tissues and biological media has been shown to induce a wide range of bioeffects that may have significant impact to therapy and diagnosis of central nervous system diseases and disorders. However, the inherently non-linear microbubble oscillations combined with the micrometer and microsecond scales involved in these interactions and the limited methods to assess and visualize them transcranially hinder both their optimal use and translation to the clinics. To overcome these challenges, we present a noninvasive and clinically relevant framework that combines numerical simulations with multimodality imaging to assess and visualize the microbubble oscillations transcranially. In the present work, acoustic cavitation was studied with an integrated US and MR imaging guided clinical FUS system in non-human primates. This multimodality imaging system allowed us to concurrently induce and visualize acoustic cavitation transcranially. A high-resolution brain CT-scan that allowed us to determine the head acoustic properties (density, speed of sound, and absorption) was also co-registered to the US and MR images. The derived acoustic properties and the location of the targets that were determined by the 3D-CT scans and the post sonication MRI respectively were then used as inputs to two- and three-dimensional Finite Difference Time Domain (2D, 3D-FDTD) simulations that matched the experimental conditions and geometry. At the experimentally-determined target locations, synthetic point sources with pressure amplitude traces derived by either a Gaussian function or the output of a microbubble dynamics model were numerically excited and propagated through the skull towards a virtual US imaging array. Then, using passive acoustic mapping that was refined to incorporate variable speed of sound, we assessed the losses and aberrations induced by the skull as a function of the acoustic em- ssions recorded by the virtual US imaging array. Next, the simulated passive acoustic maps (PAMs) were compared to experimental PAMs.
Finally, using clinical CT and MR imaging as input to the numerical simulations, we evaluated the clinical utility of the proposed framework. The simulations indicated that the diverging pressure waves propagating through the skull lose 95% of their intensity as compared to propagation in water—only. Further, the incorporation of a variable speed of sound to the PAM back—projection algorithm indeed corrected the aberrations introduced by the skull and substantially improved the resolution. More than 94% agreement in the FWHM of the axial and transverse line profiles between the simulations incorporating microbubble emissions and experimentally-determined PAMs was observed. Finally, the results of the 2D simulations that used clinical datasets are promising for the prospective use of transcranial PAM in a human with an 82 mm aperture broadband linear array. Incorporation of variable speed of sound to the PAM back-projection algorithm appeared capable of correcting the aberrations introduced by the human skull. These results suggest that this integrated approach can provide a physically accurate and clinically-relevant framework for developing a comprehensive treatment guidance for therapeutic applications of acoustic cavita timately it may enable the quantification of the emissions and provide more control over this nonlinear process
Related Matlab Project Titles:
- Microstructural characterization of the pia-arachnoid complex using optical coherence tomography.
- Benchmark for algorithms segmenting the left atrium from 3D CT and MRI datasets.
- Analysis of Laser Speckle Contrast Images Variability Using a Novel Empirical Mode Decomposition: Comparison of Results With Laser Doppler Flowmetry Signals Variability
- Axially Elongated Field-Free Point Data Acquisition in Magnetic Particle Imaging.
- Geodesic atlas-based labeling of anatomical trees: Application and evaluation on airways extracted from CT.
- Fast and Robust Design of Time-Optimal k-Space Trajectories in MRI.
- Fast X-Ray CT Image Reconstruction Using a Linearized Augmented Lagrangian Method With Ordered Subsets.
- Spinal Navigation and Imaging: History, Trends and Future.
- A Pipeline for the Generation of Realistic 3D Synthetic Echocardiographic Sequences: Methodology and Open-access Database.
- Automated 3-D Retinal Layer Segmentation of Macular Optical Coherence Tomography Images With Serous Pigment Epithelial Detachments.
- Fast Parallel MR Image Reconstruction via B1-Based, Adaptive Restart, Iterative Soft Thresholding Algorithms (BARISTA).
- Ultrasound Shear Wave Elasticity Imaging Quantifies Coronary Perfusion Pressure Effect on Cardiac Compliance.
- The Evaluation of Data Completeness and Image Quality in Multiplexing Multi-Pinhole SPECT.
- Vertebroplasty Performance on Simulator for 19 Surgeons Using Hierarchical Task Analysis.
- Multi-Dimensional Flow-Preserving Compressed Sensing (MuFloCoS) for Time-Resolved Velocity-Encoded Phase Contrast MRI.
- Regularization Designs for Uniform Spatial Resolution and Noise Properties in Statistical Image Reconstruction for 3-D X-ray CT.
- Including Signal Intensity Increases the Performance of Blind Source Separation on Brain Imaging Data.
- A Model of Population and Subject (MOPS) Intensities with Application to Multiple Sclerosis Lesion Segmentation.
- Multi-Target Tracking with Time-Varying Clutter Rate and Detection Profile: Application to Time-lapse Cell Microscopy Sequences.
We want to support Uncompromise Matlab service for all your Requirements Our Reseachers and Technical team keep update the technology for all subjects ,We assure We Meet out Your Needs.
- Matlab Research Paper Help
- Matlab assignment help
- Matlab Project Help
- Matlab Homework Help
- Simulink assignment help
- Simulink Project Help
- Simulink Homework Help
- Matlab Research Paper Help
- NS3 Research Paper Help
- Omnet++ Research Paper Help
- Customised Matlab Assignments
- Global Assignment Knowledge
- Best Assignment Writers
- Certified Matlab Trainers
- Experienced Matlab Developers
- Over 400k+ Satisfied Students
- Ontime support
- Best Price Guarantee
- Plagiarism Free Work
- Correct Citations
Unlimited support we offer you
For better understanding purpose we provide following Materials for all Kind of Research & Assignment & Homework service.
- Result snapshot
- Video Tutorial
- Instructions Profile
- Sofware Install Guide
- Execution Guidance
- Implement Plan
Matlab projects innovators has laid our steps in all dimension related to math works.Our concern support matlab projects for more than 10 years.Many Research scholars are benefited by our matlab projects service.We are trusted institution who supplies matlab projects for many universities and colleges.
Reasons to choose Matlab Projects .org???
Our Service are widely utilized by Research centers.More than 5000+ Projects & Thesis has been provided by us to Students & Research Scholars. All current mathworks software versions are being updated by us.
Our concern has provided the required solution for all the above mention technical problems required by clients with best Customer Support.
- Novel Idea
- Ontime Delivery
- Best Prices
- Unique Work